Seminarium - Molecular Explanations for the Toxicity of Oxygen, Prof. James Inlay

  • Datum: –17.00
  • Plats: Biomedicinskt centrum C8:305
  • Föreläsare: Prof. James Inlay, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign
  • Arrangör: Ass.Prof. Julia Griese
  • Kontaktperson: Julia Griese
  • Seminarium

James is a biochemist who has dedicated his career to studying the molecular mechanisms of oxygen toxicity.

Abstract: For more than 100 years we have understood that high levels of oxygen are overtly toxic and that lower levels chronically damage organisms of all types. Much of this toxicity is mediated by partially reduced forms of oxygen: superoxide, hydrogen peroxide, and the hydroxyl radical; in other cases, molecular oxygen itself is the culprit. It has been challenging to determine the types of molecular injuries these various species can create, how cells defend themselves against them, and in what circumstances oxidative stress determines cell fate. We are finally finding answers to these questions, and it is satisfying to recognize that these answers fit well to what we understand about the chemical natures of these distinct oxidants.